• The Marvel Comics film from 20th Century Fox debuted in North American with $125 million
  • Its opening was enough to dethrone “Avengers: Infinity War’s” reign on the domestic box office no. 1 spot

Superheroes continue to dominate the box office as Deadpool and his crew of misfits have dethroned the Avengers from the No. 1 spot.

Ryan Reynolds and 20th Century Fox’s Deadpool 2 debuted to $125 million domestically and $301 million globally after scoring the biggest foreign debut in history.

Deadpool 2’s opening was enough to crush “Avengers: Infinity War’s” reign on the domestic box office. After securing the No. 1 spot for three weeks, the Disney and Marvel superhero movie dropped to second place.

Though the studio fell short of their prediction of $130 million and the $132.4 million that its predecessor earned two years ago, analysts and the studio said the difference can be attributed to the first film opening on a holiday weekend, and could easily be made up with Memorial Day coming, despite the looming competition from “Solo: A Star Wars Story.”

“I think with a holiday on our second weekend we’ll catch ‘Deadpool’ if not exceed it,” said Chris Aronson, distribution chief for 20th Century Fox.